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Cymbalta Side Effects


Lilly's press release did not even address side effects, but another of their releases regarding Cymbalta's clinical trials revealed three of the exact same side effects as other antidepressants: Dizziness, anxiety, and nausea.

Although the mechanism of the antidepressant action of duloxetine in humans is unknown, it is believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS. Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic or histaminergic receptors in vitro. Duloxetine does not inhibit monoamine oxidase (MAO). Duloxetine undergoes extensive metabolism, but the major circulating metabolites have not been shown to contribute significantly to the pharmacologic activity of duloxetine.

Find information on Cymbalta uses, how cymbalta works and other basics

Duloxetine has been evaluated for safety in 2418 patients diagnosed with major depressive disorder who participated in multiple-dose premarketing trials, representing 1099 patient-years of exposure.

The stated frequencies of adverse events represent the proportion of individuals who experienced, at least once, a treatment-emergent adverse event of the type listed. An event was considered treatment-emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation. Events reported during the studies were not necessarily caused by the therapy, and the frequencies do not reflect investigator impression of causality.

Other common side effects of Cymbalta are:

  • dry mouth,
  • constipation,
  • decreased appetite,
  • fatigue,
  • sleepiness, and
  • increased sweating.

Warnings and precautions for Cymbalta:

  • Anafranil should not be given in conjunction with or within 14 days of treatment with a MAO inhibitor.
  • Tell your doctor if you are allergic to any drug.
  • Duloxetine is contraindicated in patients with a known hypersensitivity to the product.
  • In clinical trials, duloxetine use was associated with an increased risk of mydriasis; therefore, its use should be avoided in patients with uncontrolled narrow-angle glaucoma.
  • If the decision has been made to discontinue treatment, medication should be tapered, as rapidly as is feasible, but with recognition that abrupt discontinuation can be associated with certain symptoms.
  • Blood pressure should be measured prior to initiating treatment and periodically measured throughout treatment
  • When duloxetine and ethanol were administered several hours apart so that peak concentrations of each would coincide, duloxetine did not increase the impairment of mental and motor skills caused by alcohol.
  • When treating a pregnant woman with Cymbalta during the third trimester, the physician should carefully consider the potential risks and benefits of treatment
  • Tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this drug.
  • Duloxetine and/or its metabolites are excreted into the milk of lactating rats. It is unknown whether or not duloxetine and/or its metabolites are excreted into human milk, but nursing while on duloxetine is not recommended.

would you send me an information about cymbalta? 30 mg cymbalta how many % serotonin has? I take celexa 20 mg a day. but I want switch with cymbalta. Do i have to start 30 or 60 mg cymbalta? my doctor is not sure. Please help me. - saadet ghaffari

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