Is there a role of Biological balance and Biotypes in the onset and prognosis of depression in people? Born with unbalanced biochemistry, many people struggle with depression for most of their life. After taking anti-depressants such as Prozac and Zoloft, or acid therapies like 5-HTP, etc. or other herbal remedies, people realize that over time, their symptoms have worsened rather than soothing. Some of these medications helped little, but due to presence of nasty side-effects they actually make you feel worse.

Lot of psychiatrists believe that depression is caused by low levels of the neurotransmitter serotonin, which makes SSRI (Selective Serotonin Reuptake Inhibitors) to be the standard medication. This approach does not consider the unique biochemical imbalances and different symptoms of each individual.

There was a research conducted by William J. Walsh, Ph.D., at the Walsh Research Institute, and clinical applications by Drs. Albert Mensah. They condicted detailed study of about 300,000 blood and urine test results and 200,000 medical history from approximately 2,800 patients diagnosed with depression, They found that there are majorly 4 depression biotypes.

Typical symptoms of Patients with different Subtypes

Patient with Subtypes 1 and 2 – these people often report more fatigue. Subtype 1 were more likelier to benefit from transcranial magnetic stimulation (TMS). Many people take the antidepresant based treatment although their subtypes wants them to be treated with TMS.

Patients of Subtypes 3 and 4 often have difficulty in feeling pleasure. Brain on one hand have reduced connectivity in its network causing depressive anxiety, fear, etc., on the other hand people with subtype 3 and 4 has hyperconnectivity between stimuli center and brain control.

This subtyping helped in greater diagnostic precision, as well as finding accurate prognosis for patients bringing lot more relief with proper indivisualized treatment.

Different Biotypes in Depressive population

1. Type 1 – Undermethylators

2. Type 2 – Overmethylators

3. Type 3 – Pyrroluria or Pyrrole Depression

4. Type 4 – Copper Overload