Cymbalta and Anxiety

Cymbalta for Anxiety

Cymbalta - a medication sometimes used to treat panic and anxiety disorders.

Generic Name: Duloxetine hydrochloride (hcl)

Brand name Cymbalta

The investigational drug Cymbalta(TM) (duloxetine HCl) demonstrated rapid relief of anxiety symptoms associated with depression that was sustained for the length of the study period, according to new data published in the journal Depression and Anxiety. In clinical studies, researchers attribute the medication's effect on a broad spectrum of depression symptoms, which include emotional and painful physical symptoms as well as anxiety, to its dual reuptake inhibition of both serotonin and norepinephrine.

Although the mechanism of the antidepressant action of duloxetine in humans is unknown, it is believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS. Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic or histaminergic receptors in vitro. Duloxetine does not inhibit monoamine oxidase (MAO). Duloxetine undergoes extensive metabolism, but the major circulating metabolites have not been shown to contribute significantly to the pharmacologic activity of duloxetine.

"As anxiety is a key symptom of depression, treating this symptom plays a significant role in the overall treatment of depression and in a patient's ability to ultimately achieve complete recovery," said David Dunner, M.D., executive director, University of Washington Center for Anxiety and Depression. "With these patients also at an increased risk for recurrence and suicide, early and effective intervention is critical to the overall health and safety of the patient."

For more information on Cymbalta:

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