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Flunarizine
Flunarizine is one of the latest calcium antagonists with 'proven' anti-migraine effect. Prevents cell damage due to calcium overload by selectively blocking the entry of calcium into the cells of tissues. It has been found to inhibit the contractions of vascular smooth muscle and protected blood cells from membrane rigidity and protect brain cells from the effects of hypoxia. Flunarizine IndicationsProphylaxis of classical and common migraine. Dosage of FlunarizineAdults: 10 mg at night; below 40 kg: 5 mg. Flunarizine ContraindicationPregnancy and lactation. Special precaution while taking FlunarizineDrowsiness may occur and patients should not drive or operate machinery. Pediatrics: reduced dose necessary Pregnancy: contraindicated Lactation: contraindicated Elderly: Use with caution. Side effects of FlunarizineDrowsiness, weight gain, headache, depression, gastric pain, dry mouth, insomnia and extrapyramidal reactions. Flunarizine Drug interactionsPlasma level reduced by phenytoin, carbamazepine, valproic acid.
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