Flunarizine

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Flunarizine is one of the latest calcium antagonists with 'proven' anti-migraine effect. Prevents cell damage due to calcium overload by selectively blocking the entry of calcium into the cells of tissues. It has been found to inhibit the contractions of vascular smooth muscle and protected blood cells from membrane rigidity and protect brain cells from the effects of hypoxia.

Flunarizine Indications

Prophylaxis of classical and common migraine.

Dosage of Flunarizine

Adults: 10 mg at night; below 40 kg: 5 mg.

Flunarizine Contraindication

Pregnancy and lactation.

Special precaution while taking Flunarizine

Drowsiness may occur and patients should not drive or operate machinery.

Pediatrics: reduced dose necessary

Pregnancy: contraindicated

Lactation: contraindicated

Elderly: Use with caution.

Side effects of Flunarizine

Drowsiness, weight gain, headache, depression, gastric pain, dry mouth, insomnia and extrapyramidal reactions.

Flunarizine Drug interactions

Plasma level reduced by phenytoin, carbamazepine, valproic acid.

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