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Sumatriptan is a specific and selective 5-hydroxytryptamine 1-like (5HT 1-like) receptor agonist with little or no effect at a variety of other receptor types. It produces a dose-related vasoconstriction in the cerebral circulation. It does not bind to alpha adrenergic, beta adrenergic, mucarinic, dopaminergic or benzodiazepine receptors. It provides relief in both the headache and other symptom such as nausea and photophobia. Sumatriptan IndicationAcute treatment for migraine, severe acute pain of a cluster headache attack. Dosage of Sumatriptan50 mg - 300 mg in 24 hours or as directed by physician. Sumatriptan ContraindicationIschemic heart disease, hypertension. Special precaution while taking SumatriptanShould not be given intravenously in patients with ischemic heart disease, hepatic impairment. Pediatrics: Not recommended Pregnancy: Should not be used Lactation: Should not be used Elderly: Use with caution. Not recommended in age above 65 years. Side effects of SumatriptanSudden wheeziness, fluttering or tightness in the chest, swelling of eyelids, face or lips, skin rash, red spots or hives. Sumatriptan Drug interactionsErgotamine, lithium and MAOIs increases the risk of side effects.
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