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Uses and side effects of Sumatriptan


Sumatriptan is a specific and selective 5-hydroxytryptamine 1-like (5HT 1-like) receptor agonist with little or no effect at a variety of other receptor types. It produces a dose-related vasoconstriction in the cerebral circulation. It does not bind to alpha adrenergic, beta adrenergic, mucarinic, dopaminergic or benzodiazepine receptors. It provides relief in both the headache and other symptom such as nausea and photophobia.

Sumatriptan Indication

Acute treatment for migraine, severe acute pain of a cluster headache attack.

Dosage of Sumatriptan

50 mg - 300 mg in 24 hours or as directed by physician.

Sumatriptan Contraindication

Ischemic heart disease, hypertension.

Special precaution while taking Sumatriptan

Should not be given intravenously in patients with ischemic heart disease, hepatic impairment.

Pediatrics: Not recommended

Pregnancy: Should not be used

Lactation: Should not be used

Elderly: Use with caution. Not recommended in age above 65 years.

Side effects of Sumatriptan

Sudden wheeziness, fluttering or tightness in the chest, swelling of eyelids, face or lips, skin rash, red spots or hives.

Sumatriptan Drug interactions

Ergotamine, lithium and MAOIs increases the risk of side effects.

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