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Tofranil benefits and side effects


Generic Name: Imipramine

Drug Class: Antidepressant, TCA

Tofranil Drug Description:

Tofranil is used primarily to treat depression. In manic depression, it may aggravate or lead to a manic episode.

In children, Tofranil is used to treat bedwetting (enuresis) in children over 5 years old. It is used as a short-term therapy for bedwetting that does not have an organic cause, and use for longer than six months can lead to a decreased effectiveness of this drug.

Find other information on Tofranil (Imipramine)

Warnings and Precautions of Tofranil:

  • Thyroid medications when taken with Tofranil can increase the risk of heart rhythm disorders.
  • Alcohol - when combined with Tofranil its intoxicating effects are increased and the combination can result in significantly depressed brain function.
  • Patients with a history of seizure disorder should be cautious because this drug has been shown to lower the seizure threshold.
  • Tofranil may produce urinary retention and should be used with caution in patients with urinary pathology, particularly in the presence of prostatic hypertrophy.
  • Tofranil should be used with caution in hyperthyroid patients or those on thyroid medication because of the possibility of cardiovascular toxicity.
  • The safety of imipramine in pregnancy has not been established. Neonates whose mothers had taken imipramine up until delivery have shown symptoms such as dyspnea, lethargy, colic, irritability, hypotension or hypertension, tremor or spasms during the first few hours or days.
  • In predisposed and elderly patients, imipramine may, particularly at night, provoke pharmacogenic (delirious) psychoses which disappear without treatment within a few days of withdrawing the drug.
  • An abrupt discontinuation of treatment should be avoided as it may give rise to withdrawal symptoms.
  • Lengthy treatment with tricyclic antidepressants can lead to an increased incidence of dental caries.
  • mipramine should be used with caution in patients with significantly impaired renal or hepatic function.
  • Patients taking imipramine should avoid excessive exposure to sunlight since there have been reports of photosensitization.
  • Both elevation and lowering of blood sugar levels have been reported with mipramine use.
  • Tofranil can cause drowsiness or trouble thinking in some people. Patients should not drive or operate heavy machinery until they know that this drug does not affect the ability to safely engage in these activities.

How Supplied:

Tablets: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg.

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